Basic Information

Symbol
TNFRSF1A
RNA class
mRNA
Alias
TNF Receptor Superfamily Member 1A TNFAR TNF-R-I TNF-R55 TNFR60 CD120a TNF-R TNFR1 Tumor Necrosis Factor Receptor Superfamily Member 1A TNF-R1 TNF-RI TNFR-I P55 P60 Tumor Necrosis Factor Receptor Superfamily, Member 1A Tumor Necrosis Factor Binding Protein 1 Tumor Necrosis Factor Receptor Type 1 Tumor Necrosis Factor Receptor Type I Tumor Necrosis Factor-Alpha Receptor Tumor Necrosis Factor Receptor 1 CD120a Antigen TNFR55 P55-R TBP1 FPF
Location (GRCh38)
12:6328757-6342114
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden death from respiratory system disease
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001065.4
Sequence length
2171.0 nt
GC content
0.5749

Transcripts

ID Sequence Length GC content
NM_001065.4 NCBI
ACUCUUCCCCUCCCACCUUCUCUCCCCUCCUCUCUGCUUUAAUUUUCUC… 2171 nt 0.5749
NM_001346091.2 NCBI
ACUCUUCCCCUCCCACCUUCUCUCCCCUCCUCUCUGCUUUAAUUUUCUC… 2017 nt 0.5811
NM_001346092.2 NCBI
ACUCUUCCCCUCCCACCUUCUCUCCCCUCCUCUCUGCUUUAAUUUUCUC… 2289 nt 0.5749
Summary

This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016]

Forensic Context

A study in mice demonstrated that the TNFRSF1A is a core hub gene in a seven-gene signature for differentiating sepsis-induced acute lung injury from sepsis, with its expression significantly correlated with ALI score and validated as increased in lung tissue of LPS-treated mice [Sun et al. DOI:10.1016/j.ijbiomac.2024.136961].