Basic Information

Symbol
TNFRSF25
RNA class
mRNA
Alias
TNF Receptor Superfamily Member 25 LARD DDR3 DR3 TNFRSF12 WSL-LR TRAMP WSL-1 APO-3 TR3 Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating Chain-Association Membrane Protein) Tumor Necrosis Factor Receptor Superfamily Member 25 Lymphocyte-Associated Receptor Of Death Apoptosis-Mediating Receptor TRAMP Apoptosis-Mediating Receptor DR3 Apoptosis-Inducing Receptor AIR Protein WSL-1 Pleckstrin Homology Domain-Containing Family G Member 5 Tumor Necrosis Factor Receptor Superfamily, Member 25 Guanine Nucleotide Exchange Factor 720 PH Domain-Containing Family G Member 5 Death Domain Receptor 3 Soluble Form Apoptosis Inducing Receptor Death Receptor Beta Death Receptor 3 Protein WSL PLEKHG5 GEF720 Apo-3 APO3 WSL1 WSL
Location (GRCh38)
1:6460786-6466181
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003790.3
Sequence length
1968.0 nt
GC content
0.6382

Transcripts

ID Sequence Length GC content
NM_001039664.2 NCBI
GAAGGCGGAACCACGACGGGCAGAGAGCACGGAGCCGGGAAGCCCCUGG… 872 nt 0.6261
NM_003790.3 NCBI
GAAGGCGGAACCACGACGGGCAGAGAGCACGGAGCCGGGAAGCCCCUGG… 1968 nt 0.6382
NM_148965.2 NCBI
GAAGGCGGAACCACGACGGGCAGAGAGCACGGAGCCGGGAAGCCCCUGG… 1995 nt 0.6391
NM_148966.2 NCBI
GAAGGCGGAACCACGACGGGCAGAGAGCACGGAGCCGGGAAGCCCCUGG… 1857 nt 0.6381
NM_148967.2 NCBI
GAAGGCGGAACCACGACGGGCAGAGAGCACGGAGCCGGGAAGCCCCUGG… 1833 nt 0.6405
NM_148970.2 NCBI
GAAGGCGGAACCACGACGGGCAGAGAGCACGGAGCCGGGAAGCCCCUGG… 1419 nt 0.6434
Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human cadavers demonstrated that the TNFRSF25 was significantly down-regulated, showing a -501.285 fold change in decaying liver tissues compared to a 6-hour control, as part of the apoptotic thanatotranscriptome where pro-apoptotic genes were up-regulated and anti-apoptotic genes were down-regulated over a 48-hour postmortem interval [Javan et al. DOI:10.1007/S12024-015-9704-6].