Basic Information

Symbol
TNFSF10
RNA class
mRNA
Alias
TNF Superfamily Member 10 Apo-2L TRAIL CD253 TANCR TL2 Tumor Necrosis Factor (Ligand) Superfamily, Member 10 Tumor Necrosis Factor Ligand Superfamily Member 10 Apo-2 Ligand APO2L Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10 Tumor Necrosis Factor (Ligand) Family, Member 10 TNF-Related Apoptosis Inducing Ligand TRAIL Tumor Necrosis Factor Superfamily Member 10 TNF-Related Apoptosis-Inducing Ligand Tumor Necrosis Factor Ligand 6A Protein TRAIL CD253 Antigen TNLG6A
Location (GRCh38)
3:172505508-172523476
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003810.4
Sequence length
1876.0 nt
GC content
0.4025

Transcripts

ID Sequence Length GC content
NM_001190942.2 NCBI
GACCGGCUGCCUGGCUGACUUACAGCAGUCAGACUCUGACAGGAUCAUG… 1728 nt 0.4010
NM_001190943.2 NCBI
GACCGGCUGCCUGGCUGACUUACAGCAGUCAGACUCUGACAGGAUCAUG… 1289 nt 0.4251
NM_003810.4 NCBI
GACCGGCUGCCUGGCUGACUUACAGCAGUCAGACUCUGACAGGAUCAUG… 1876 nt 0.4025
Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Forensic Context

A study in human prostate tissues from cadavers demonstrated that the TNFSF10 was not significantly upregulated at shorter postmortem intervals and was down-regulated at the initial 38-hour time point [Tolbert et al. DOI:10.1016/j.gene.2018.06.090]. In a separate investigation of human skin wound healing, the TNFSF10 was identified as a marker expressed in a specific spinous keratinocyte subtype (Spi-III) during the re-epithelialization process [Liu et al. DOI:10.1016/j.stem.2024.11.013].