Basic Information

Symbol
TNFSF13B
RNA class
mRNA
Alias
TNF Superfamily Member 13b TALL-1 TALL1 BAFF BLYS B-Cell-Activating Factor TNFSF20 THANK CD257 Tumor Necrosis Factor (Ligand) Superfamily, Member 13b Tumor Necrosis Factor Ligand Superfamily Member 13B TNF And ApoL-Related Leukocyte Expressed Ligand 1 Dendritic Cell-Derived TNF-Like Molecule TNF Homolog That Activates Apoptosis B-Lymphocyte Stimulator ZTNF4 Tumor Necrosis Factor (Ligand) Superfamily, Member 20 TNF- And APOL-Related Leukocyte Expressed Ligand 1 Tumor Necrosis Factor Superfamily Member 13b Epididymis Secretory Sperm Binding Protein Tumor Necrosis Factor-Like Protein ZTNF4 Tumor Necrosis Factor Ligand 7A ApoL Related Ligand TALL-1 B Lymphocyte Stimulator CD257 Antigen Delta4 BAFF Delta BAFF TNLG7A BLyS DTL
Location (GRCh38)
13:108251240-108308484
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006573.5
Sequence length
2576.0 nt
GC content
0.3672

Transcripts

ID Sequence Length GC content
NM_001145645.2 NCBI
GAAAUUCUUACAAAAACUGAAAGUGAAAUGAGGAAGACAGAUUGAGCAA… 2618 nt 0.3671
NM_006573.5 NCBI
AGGGGUAGAGAUGCAGAAAGGCAGAAAGGAGAAAAUUCAGGAUAACUCU… 2576 nt 0.3672
Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Forensic Context

A study in human skin demonstrated that the TNFSF13B gene was significantly up-regulated in thermally injured tissue compared to normal skin during the early wound repair process following partial-thickness burn injury [Greco et al. DOI:10.1016/j.burns.2009.06.211].