Basic Information

Symbol
TNFSF14
RNA class
mRNA
Alias
TNF Superfamily Member 14 LIGHT HVEM-L CD258 LTg Tumor Necrosis Factor (Ligand) Superfamily, Member 14 Tumor Necrosis Factor Ligand Superfamily Member 14 Herpesvirus Entry Mediator Ligand HVEML Tumor Necrosis Factor Superfamily Member 14 Herpes Virus Entry Mediator Ligand Tumor Necrosis Factor Ligand 1D CD258 Antigen
Location (GRCh38)
19:6658085-6670621
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001376887.1
Sequence length
4487.0 nt
GC content
0.5130

Transcripts

ID Sequence Length GC content
NM_001376887.1 NCBI
AGCGUGCACAGCCCAGGAGUGUUGAGCAAUUUCGGUUUCCUCUGAGGUU… 4487 nt 0.5130
NM_003807.5 NCBI
CGAGACUCCAUCUCAAAAACAAAACAAAUAAACGAACAAAAAAACCCAC… 4778 nt 0.5117
NM_172014.3 NCBI
CGUGCACAGCCCAGGAGUGUUGAGCAAUUUCGGUUUCCUCUGAGGUUGA… 4406 nt 0.5061
Summary

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans investigated the TNFSF14 as a candidate mRNA marker for predicting the time-of-day of bloodstain deposition [Gosch et al. DOI:10.1101/2025.02.03.636230][Gosch et al. DOI:10.1016/J.Fsigen.2025.103287]. The TNFSF14 was excluded from the final targeted sequencing panel after initial testing due to a lack of statistically significant expression differences across the eight sampled time points, and it was therefore not included in the final penalised regression prediction model.