Basic Information

Symbol
TNFSF8
RNA class
mRNA
Alias
TNF Superfamily Member 8 CD30LG CD153 Tumor Necrosis Factor (Ligand) Superfamily, Member 8 Tumor Necrosis Factor Ligand Superfamily Member 8 CD153 Antigen CD30 Ligand CD30-L CD30L Tumor Necrosis Factor Superfamily Member 8 Tumor Necrosis Factor Ligand 3A CD30 Antigen Ligand TNLG3A
Location (GRCh38)
9:114893343-114930595
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001244.4
Sequence length
3779.0 nt
GC content
0.4427

Transcripts

ID Sequence Length GC content
NM_001244.4 NCBI
GUCAUUUUCCUACGCGCCCUCUGACAUCAGCCACCUUCUCUGUAGCUAG… 3779 nt 0.4427
NM_001252290.1 NCBI
AACCGUCAUUUUCCUACGCGCCCUCUGACAUCAGCCACCUUCUCUGUAG… 1526 nt 0.4699
Summary

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Forensic Context

A study in human postmortem prostate tissues demonstrated that the TNFSF8 was significantly upregulated at longer postmortem intervals of 96 and 120 hours compared to a 24-hour control, as validated by PCR array and statistical analysis [Tolbert et al. DOI:10.1016/j.gene.2018.06.090].