Basic Information

Symbol
TNIK
RNA class
mRNA
Alias
TRAF2 And NCK Interacting Kinase KIAA0551 TRAF2 And NCK-Interacting Protein Kinase EC 2.7.11.1 EC 2.7.11 MRT54
Location (GRCh38)
3:171058414-171460408
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015028.4
Sequence length
9892.0 nt
GC content
0.4287

Transcripts

ID Sequence Length GC content
NM_001161560.3 NCBI
AUAACAGCCAAUGCAGCCGCCAUCCACGCACAAGCAAAGAAGCAUGUCC… 9868 nt 0.4290
NM_001161561.3 NCBI
AUAACAGCCAAUGCAGCCGCCAUCCACGCACAAGCAAAGAAGCAUGUCC… 9805 nt 0.4283
NM_001161562.3 NCBI
AUAACAGCCAAUGCAGCCGCCAUCCACGCACAAGCAAAGAAGCAUGUCC… 9781 nt 0.4285
NM_001161563.3 NCBI
AUAACAGCCAAUGCAGCCGCCAUCCACGCACAAGCAAAGAAGCAUGUCC… 9727 nt 0.4262
NM_001161564.3 NCBI
AUAACAGCCAAUGCAGCCGCCAUCCACGCACAAGCAAAGAAGCAUGUCC… 9703 nt 0.4265
NM_001161565.3 NCBI
AUAACAGCCAAUGCAGCCGCCAUCCACGCACAAGCAAAGAAGCAUGUCC… 9640 nt 0.4257
NM_001161566.3 NCBI
AUAACAGCCAAUGCAGCCGCCAUCCACGCACAAGCAAAGAAGCAUGUCC… 9616 nt 0.4260
NM_015028.4 NCBI
AUAACAGCCAAUGCAGCCGCCAUCCACGCACAAGCAAAGAAGCAUGUCC… 9892 nt 0.4287
Summary

Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]

Forensic Context

A study in human blood samples stored at 4°C identified the TNIK as one of 13 downregulated transcripts that overlapped with important variables in a random forest model for predicting the time since deposition of bloodstains [Zhang et al. DOI:10.1016/j.forsciint.2024.111930]. This model, based on transcriptomic changes, successfully predicted TSD with high accuracy (AUC=0.995, precision=1, recall=1), and the TNIK was characterized as a potential time-marker transcript for forensic application.