Basic Information

Symbol
TNIP1
RNA class
mRNA
Alias
TNFAIP3 Interacting Protein 1 ABIN-1 NAF1 VAN KIAA0113 A20-Binding Inhibitor Of NF-Kappa-B Activation 1 Virion-Associated Nuclear Shuttling Protein TNFAIP3-Interacting Protein 1 HIV-1 Nef-Interacting Protein Nef-Associated Factor 1 SNP Nip40-1 Virion-Associated Nuclear-Shuttling Protein Nef-Associated Factor 1 Naf1 HVAN
Location (GRCh38)
5:151029939-151093577
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006058.5
Sequence length
2870.0 nt
GC content
0.5885

Transcripts

ID Sequence Length GC content
NM_001364487.2 NCBI
ACUUCCUCGUCCUCGGCCCGGGUGCCCUGCCCCCGUCCAGGAGCCCUAG… 2678 nt 0.5829
NM_006058.5 NCBI
ACUUCCUCGUCCUCGGCCCGGGUGCCCUGCCCCCGUCCAGGAGCCCUAG… 2870 nt 0.5885
Showing 11 to 12 of 12 entries
Summary

This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Forensic Context

A study in humans demonstrated that the TNIP1 was downregulated during long-term weight loss (0 to 12 months) in weight losers within subcutaneous adipose tissue [Bollepalli et al. DOI:10.1038/ijo.2017.245].