Basic Information

Symbol
TNIP2
RNA class
mRNA
Alias
TNFAIP3 Interacting Protein 2 FLIP1 Fetal Liver LKB1-Interacting Protein ABIN-2 ABIN2 KLIP A20-Binding Inhibitor Of NF-KappaB Activation-2 TNFAIP3-Interacting Protein 2 MGC4289 A20-Binding Inhibitor Of NF-Kappa-B Activation 2
Location (GRCh38)
4:2741648-2756367
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_024309.4
Sequence length
1946.0 nt
GC content
0.6146

Transcripts

ID Sequence Length GC content
NM_001161527.2 NCBI
GCGGAAGUUGCCGGCGGCCGCGCGGCCUCCCGGGCGGGCCUACAGCCAU… 2011 nt 0.6186
NM_001292016.2 NCBI
GCGGAAGUUGCCGGCGGCCGCGCGGCCUCCCGGGCGGGCCUACAGCCAU… 1697 nt 0.6158
NM_024309.4 NCBI
GCGGAAGUUGCCGGCGGCCGCGCGGCCUCCCGGGCGGGCCUACAGCCAU… 1946 nt 0.6146
Summary

This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

Forensic Context

A study in mice demonstrated that the TNIP2 was up-regulated at 1 day post-injury in skeletal muscle specifically following a local hind limb burn, but not after a distant dorsum burn, indicating its role in a local, injury-specific immuno-inflammatory response [Padfield et al. DOI:10.01.ta.0000230567.56797.6c]. In a porcine model of blunt trauma, TNFAIP3 expression in subcutaneous fat was up-regulated at 1-3 hours post-impact and then down-regulated, and its expression signature was part of a validated 13-gene model capable of predicting bruise age with a precision of approximately ±2 hours [Barington et al. DOI:10.007/s12024-017-9869-2].