Basic Information

Symbol
TNN
RNA class
mRNA
Alias
Tenascin N TNW Tenascin-W Tenascin-N TN-W TN-N Tenascin W
Location (GRCh38)
1:175067509-175148075
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_022093.2
Sequence length
5042.0 nt
GC content
0.5609

Transcripts

ID Sequence Length GC content
NM_022093.2 NCBI
GAGACGAGAACCAGGGACGACCAGCAAGUACCAAGGUCUGCGGCAGGAG… 5042 nt 0.5609
Summary

Predicted to enable integrin binding activity. Involved in positive regulation of sprouting angiogenesis; regulation of cell adhesion; and regulation of cell migration. Located in collagen-containing extracellular matrix. Part of tenascin complex. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in mice demonstrated that following a moderate unilateral cervical contusion injury, the endogenous level of the TNN exhibited a significant 3.7-fold increase at the lesion site 30 minutes post-injury, which gradually decreased to 0.2-fold by 7 days, with minimal changes in rostral and caudal spinal cord segments and a delayed 2.62-fold increase in the ipsilateral prefrontal motor cortex at 7 days [Yu et al. DOI:10.3390/ijms25053058].