Basic Information

Symbol
TNNT2
RNA class
mRNA
Alias
Troponin T2, Cardiac Type CMPD2 Cardiomyopathy, Dilated 1D (Autosomal Dominant) Cardiomyopathy, Hypertrophic 2 Troponin T Type 2 (Cardiac) Troponin T, Cardiac Muscle CMD1D CMH2 CTnT Cardiac Muscle Troponin T LVNC6 RCM3 TnTC TnTc
Location (GRCh38)
1:201359002-201379773
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001276345.2
Sequence length
1165.0 nt
GC content
0.5665

Transcripts

ID Sequence Length GC content
NM_000364.4 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1156 nt 0.5649
NM_001001430.3 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1135 nt 0.5665
NM_001001431.3 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1126 nt 0.5648
NM_001001432.3 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1117 nt 0.5676
NM_001276345.2 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1165 nt 0.5665
NM_001276346.2 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1036 nt 0.5695
NM_001276347.2 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1268 nt 0.5631
NM_001406723.1 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1289 nt 0.5617
NM_001406724.1 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1126 nt 0.5657
NM_001406725.1 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1132 nt 0.5671
Showing 1 to 10 of 13 entries
Summary

T his gene encodes t he cardiac isoform of t roponin T . T he encoded pro t ein is t he t ropomyosin-binding subuni t of t he t roponin complex, which is loca t ed on t he t hin filamen t of s t ria t ed muscles and regula t es muscle con t rac t ion in response t o al t era t ions in in t racellular calcium ion concen t ra t ion. Mu t a t ions in t his gene have been associa t ed wi t h familial hyper t rophic cardiomyopa t hy as well as wi t h dila t ed cardiomyopa t hy. [provided by RefSeq, May 2022]

Forensic Context

A study in humans and mice demonstrated that the TNNT2 was used as a reference gene for single-molecule fluorescence in situ hybridization (smFISH) quantification to normalize signals from other cardiac stress markers, such as NPPB and ANKRD1, in myocardial tissue [Kuppe et al. DOI:10.1038/s41586-022-05060-x]. A study in rats demonstrated that the TNNT2 shows depletion from groups of cardiomyocytes as early as 1 hour after left anterior descending coronary artery ligation, serving as an early marker of myocardial ischemia [Sabatasso et al. DOI:10.1007/S00414-016-1401-9]. A review of post-mortem interval estimation techniques further indicates that the TNNT2 degrades into fragments as the post-mortem interval advances, with the most degradation occurring in the first 50 hours and remaining detectable up to 230 hours post-mortem in human and other species' tissues [Lopez et al. DOI:10.1016/J.Forsciint.2025.112412].