Basic Information

Symbol
TNNT2
RNA class
mRNA
Alias
Troponin T2, Cardiac Type CMPD2 Cardiomyopathy, Dilated 1D (Autosomal Dominant) Cardiomyopathy, Hypertrophic 2 Troponin T Type 2 (Cardiac) Troponin T, Cardiac Muscle CMD1D CMH2 CTnT Cardiac Muscle Troponin T LVNC6 RCM3 TnTC TnTc
Location (GRCh38)
1:201359002-201379773
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001276345.2
Sequence length
1165.0 nt
GC content
0.5665

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-392.70 kcal/mol
Thermodynamic ensemble
Free energy: -410.97 kcal/mol
Frequency: 0.0000
Diversity: 349.27
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((((((..(((.((....))...)))..))..(((((((((((((((((.....)))))....(((((.(((........))).)))))..............................))))))))))))......((.(((((((.(((.(.((.(((..(.(((.(((....(((((........))))).(((....)))...........((((.((((.................................((((......))))...((((....)))).......)))).)))).))).))).)..))).)).)))))).)).)))))((((..(..((((....))))..)..))))..(((((.((((.((..(..((.((((......((((.((((((..((((..((..((((((((.......(((((((.........))).))))))))))))..))..)))).)).))))..))))..))))))...)..)))))).)))))....)))))).))....((((.....))))((((.((..(((.((((((.....)))(((.(((((..(.((.((...(((.((((.(.(((((((.........((((((((........(((.((((((((....).))))))))))......))))))))....((.((((..(((((((.((.(((.((((.............)))).))).)).(((((.(((((((((((.((..((..((((.......))))....))..)).)))))..((((.(.((((((...(((....(((((((((......(((.((((((..((((((..........((......)).........))))))....)))).)))))............)))))))))......(((((((....((...((((((.(((....))).)))))).))))))).))..))))))))).)..)))))))))).)))))...)))).))).)))).)).)))))))))))).))).)))).)....))))).))).....(((((.((.(((...(((((......)))))...))).)))))))..))).)))..))))))........................
Thermodynamic Ensemble Prediction
..((,((,((.({{,,.{(({{..{((..({{..,)}},,|||,,|||||{,|||.,}}},)}}|{{{.{{,,{.|||,.......}|,,|||||{{.....({(..{{.{{{{,{{{{{,.....,,}|||||||.......((.(((((((.(.({(..({....}|.(((((.(((((((({{,....,..||||,.,{|....|}}....{{,.{,.{{|{.{{{(..........................,....,.((((......))))}..{{{{.,,,|||,......,||||,|||}{|||.|||{|..|||,|},}|||||,,,.|||||((((..{..(({(....))))..,..)))),.(((((.((((.((..,..((.((((......((((.(((({(..((((..((..((((((({......,{{,,((.(((......))).))))))))))))..))..)))).}).))))..))))..))))))...}..)))))).)))))....,,})))}},.|,.|{||},,,,),)))}||}}...,.,.||||||..{{{{.,((((((.(({.{{(((((.{((((..((((((((((,..........)))))))))).......(((.((((((({....}.)))))))))).{{{{.|||..|||......{((((..,,((,(({((.{{{,({,,...........,,||||{},|.,|.(((((.,{{(,((((((.((..((..((((.......))))....))..)).))))}...,(({({.,,.((((.(((....((((,(((,.({,...|})..}||,}}}||}}.})))..))}}},......,,...,|..,.)))))}....))))}))..}.....}}....})))))),,,.}}}}}.,,..,|}}...))).{{||||.(({....))),))))}}))))))}}.,,...).))).)))))),))))}.,))))))))..))))).))),})))})))))||||||,,,,}))).))||{||||||||))))}}||...{((((.({.{{{...(((((......))))),,,))).))))))}..,)).)))).,.)),))}........))}))}}...,,..

Transcripts

ID Sequence Length GC content
NM_001406726.1 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1259 nt 0.5616
NM_001406727.1 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1117 nt 0.5640
NM_001406728.1 NCBI
AGUCCCCGCUGAGACUGAGCAGACGCCUCCAGGAUCUGUCGGCAGCUGC… 1120 nt 0.5679
Showing 11 to 13 of 13 entries
Summary

T his gene encodes t he cardiac isoform of t roponin T . T he encoded pro t ein is t he t ropomyosin-binding subuni t of t he t roponin complex, which is loca t ed on t he t hin filamen t of s t ria t ed muscles and regula t es muscle con t rac t ion in response t o al t era t ions in in t racellular calcium ion concen t ra t ion. Mu t a t ions in t his gene have been associa t ed wi t h familial hyper t rophic cardiomyopa t hy as well as wi t h dila t ed cardiomyopa t hy. [provided by RefSeq, May 2022]

Forensic Context

A study in humans and mice demonstrated that the TNNT2 was used as a reference gene for single-molecule fluorescence in situ hybridization (smFISH) quantification to normalize signals from other cardiac stress markers, such as NPPB and ANKRD1, in myocardial tissue [Kuppe et al. DOI:10.1038/s41586-022-05060-x]. A study in rats demonstrated that the TNNT2 shows depletion from groups of cardiomyocytes as early as 1 hour after left anterior descending coronary artery ligation, serving as an early marker of myocardial ischemia [Sabatasso et al. DOI:10.1007/S00414-016-1401-9]. A review of post-mortem interval estimation techniques further indicates that the TNNT2 degrades into fragments as the post-mortem interval advances, with the most degradation occurring in the first 50 hours and remaining detectable up to 230 hours post-mortem in human and other species' tissues [Lopez et al. DOI:10.1016/J.Forsciint.2025.112412].