Basic Information

Symbol
TNPO1
RNA class
mRNA
Alias
Transportin 1 MIP1 MIP TRN KPNB2 IPO2 Karyopherin (Importin) Beta 2 M9 Region Interaction Protein Karyopherin Beta-2 Transportin-1 Importin 2 Importin Beta 2 Importin Beta-2
Location (GRCh38)
5:72816312-72916741
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002270.4
Sequence length
8489.0 nt
GC content
0.3599

Transcripts

ID Sequence Length GC content
NM_001364292.3 NCBI
GUUCCGCAGCCAUUUCAGGCCCCGGACAGGAGGCAGUGCCGCUUCGGCC… 8691 nt 0.3691
NM_001364293.3 NCBI
CCUUGCGCUCGGCGGCCGCGGCGGCAGCAGCAGCAGACGCUGGCGGCCG… 8506 nt 0.3607
NM_001364294.3 NCBI
CCUUGCGCUCGGCGGCCGCGGCGGCAGCAGCAGCAGACGCUGGCGGCCG… 8414 nt 0.3604
NM_001364295.3 NCBI
GUUCCGCAGCCAUUUCAGGCCCCGGACAGGAGGCAGUGCCGCUUCGGCC… 8339 nt 0.3599
NM_001364296.2 NCBI
CCUUGCGCUCGGCGGCCGCGGCGGCAGCAGCAGCAGACGCUGGCGGCCG… 1813 nt 0.4043
NM_002270.4 NCBI
GUUCCGCAGCCAUUUCAGGCCCCGGACAGGAGGCAGUGCCGCUUCGGCC… 8489 nt 0.3599
NM_153188.4 NCBI
CCUUGCGCUCGGCGGCCGCGGCGGCAGCAGCAGCAGACGCUGGCGGCCG… 8510 nt 0.3609
Summary

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins. [provided by RefSeq, Jun 2018]

Forensic Context

A study in zebrafish demonstrated that the TNPO1 transcript, a nuclear import protein, increased in abundance at 4 and 12 hours postmortem [Pozhitkov et al. DOI:10.1098/rsob.160267]. A study in Sprague-Dawley rats and NRK-52E cells demonstrated that burn sepsis significantly elevated serum levels of the chemokine MIP-1α, alongside other inflammatory mediators, and promoted macrophage infiltration into kidney tissue [Yu et al. DOI:10.007/s00068-022-02124-5].