Basic Information

Symbol
TNPO3
RNA class
mRNA
Alias
Transportin 3 TRN-SR IPO12 TRN-SR2 MTR10A Limb Girdle Muscular Dystrophy 1F (Autosomal Dominant) Transportin-SR Transportin-3 Importin 12 LGMD1F Imp12 Importin-12 LGMDD2 TRNSR
Location (GRCh38)
7:128954180-129055173
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_012470.4
Sequence length
4345.0 nt
GC content
0.4723

Transcripts

ID Sequence Length GC content
NM_001191028.3 NCBI
AAACGAACCUUAGGUACACUGGUGUGUGGCCUCCCAAGAUAGGCUUCUG… 4153 nt 0.4703
NM_001382216.1 NCBI
AAACGAACCUUAGGUACACUGGUGUGUGGCCUCCCAAGAUAGGCUUCUG… 4447 nt 0.4716
NM_001382217.1 NCBI
AAACGAACCUUAGGUACACUGGUGUGUGGCCUCCCAAGAUAGGCUUCUG… 4426 nt 0.4742
NM_001382218.1 NCBI
AAACGAACCUUAGGUACACUGGUGUGUGGCCUCCCAAGAUAGGCUUCUG… 4253 nt 0.4712
NM_001382219.1 NCBI
AAACGAACCUUAGGUACACUGGUGUGUGGCCUCCCAAGAUAGGCUUCUG… 4237 nt 0.4720
NM_001382220.1 NCBI
AAACGAACCUUAGGUACACUGGUGUGUGGCCUCCCAAGAUAGGCUUCUG… 4204 nt 0.4712
NM_001382221.1 NCBI
AAACGAACCUUAGGUACACUGGUGUGUGGCCUCCCAAGAUAGGCUUCUG… 4201 nt 0.4756
NM_001382222.1 NCBI
AAACGAACCUUAGGUACACUGGUGUGUGGCCUCCCAAGAUAGGCUUCUG… 4198 nt 0.4736
NM_001382223.1 NCBI
AAACGAACCUUAGGUACACUGGUGUGUGGCCUCCCAAGAUAGGCUUCUG… 4061 nt 0.4691
NM_012470.4 NCBI
AAACGAACCUUAGGUACACUGGUGUGUGGCCUCCCAAGAUAGGCUUCUG… 4345 nt 0.4723
Summary

The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Several protein-coding and non-coding transcript variants have been found for this gene. [provided by RefSeq, Apr 2020]

Forensic Context

A study in humans undergoing cardiac surgery with cardiopulmonary bypass demonstrated that acute left ventricular ischemia induces differential expression of 21 miRNAs, including upregulated miR-339-5p and miR-483-3p and downregulated miR-139-5p [Saddic et al. DOI:10.1152/physiolgenomics.00049.2015].