Basic Information

Symbol
TNXB
RNA class
mRNA
Alias
Tenascin XB HXBL TN-X TNX XB Hexabrachion-Like Protein Tenascin-X TNXBS TNXB1 TNXB2 XBS Growth-Inhibiting Protein 45 Tenascin XB1 Tenascin XB2 EDSCLL1 EDSCLL EDS3 TENX VUR8
Location (GRCh38)
6:32041153-32115334
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001365276.2
Sequence length
13097.0 nt
GC content
0.6479

Transcripts

ID Sequence Length GC content
NM_001365276.2 NCBI
CUCCUCACUGUCGCUGCCGAGAUCCACAGUCGGUUGUGGCUCAGCCCCU… 13097 nt 0.6479
NM_001428335.1 NCBI
CUCCUCACUGUCGCUGCCGAGAUCCACAGUCGGUUGUGGCUCAGCCCCU… 13838 nt 0.6523
NM_019105.8 NCBI
CUCCUCACUGUCGCUGCCGAGAUCCACAGUCGGUUGUGGCUCAGCCCCU… 13091 nt 0.6478
NM_032470.4 NCBI
CCUUGUGCAUUUGGGCUGAAGACAAAGAUGACUGCAGGAGUGGGCAGGC… 3127 nt 0.6310
Summary

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

No relevant information is available at the moment.