Basic Information

Symbol
TOX
RNA class
mRNA
Alias
Thymocyte Selection Associated High Mobility Group Box KIAA0808 TOX1 Thymocyte Selection-Associated High Mobility Group Box Protein TOX Thymus High Mobility Group Box Protein TOX
Location (GRCh38)
8:58805412-59119279
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Postmortem interval inference Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014729.3
Sequence length
4076.0 nt
GC content
0.4105

Transcripts

ID Sequence Length GC content
NM_014729.3 NCBI
CUCUUCUUCUUAAACAAACCACAAACGGAUGUGAGGGAAGGAAGGUGUU… 4076 nt 0.4105
Summary

The protein encoded by this gene contains a HMG box DNA binding domain. HMG boxes are found in many eukaryotic proteins involved in chromatin assembly, transcription and replication. This protein may function to regulate T-cell development.[provided by RefSeq, Apr 2009] CIViC Summary for TOX Gene

Forensic Context

A study in human traumatic brain injury (TBI) patients demonstrated that the mRNA for TOX (thymocyte selection associated high mobility group box) was part of a negatively correlated lncRNA-mRNA pair in a co-expression network constructed from differentially expressed transcripts in brain contusion tissue [Yang et al. DOI:10.4103/1673-5374.247467]. In a separate investigation of postmortem transcriptome dynamics in zebrafish, the TOX transcript abundance increased after 12 hours postmortem, reaching a maximum at 24 hours [Pozhitkov et al. DOI:10.1098/rsob.160267].