Basic Information

Symbol
TOX3
RNA class
mRNA
Alias
TOX High Mobility Group Box Family Member 3 CAGF9 TNRC9 CAG Trinucleotide Repeat-Containing Gene F9 Protein Trinucleotide Repeat-Containing Gene 9 Protein Trinucleotide Repeat Containing 9
Location (GRCh38)
16:52436417-52547802
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001080430.4
Sequence length
4959.0 nt
GC content
0.4400

Transcripts

ID Sequence Length GC content
NM_001080430.4 NCBI
GUCUCCGCGGCUCGUCUCCUCAGUCCGCCCGGGGAGGAGGAGGAGGAGC… 4959 nt 0.4400
NM_001146188.2 NCBI
GAACCGACACGAGGCUUCACCUGGGAAGCUUCAAGUCUGCCUACCUGUG… 4713 nt 0.4044
Summary

The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]

Forensic Context

A study in rhesus macaques demonstrated that whole-thorax irradiation induced significant transcriptomic dysregulation in lung tissue, where TOX3 was identified as one of the top downregulated transcripts among common differentially expressed genes in irradiated animals [Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058]. This downregulation was associated with increased epithelial-mesenchymal transition, a key process in radiation-induced lung injury progression.