Basic Information

Symbol
TP53BP2
RNA class
mRNA
Alias
Tumor Protein P53 Binding Protein 2 ASPP2 53BP2 PPP1R13A Apoptosis-Stimulating Of P53 Protein 2 Tumor Suppressor P53-Binding Protein 2 Renal Carcinoma Antigen NY-REN-51 P53BP2 BBP Apoptosis-Stimulating Protein Of P53, 2 Tumor Protein P53-Binding Protein, 2 P53-Binding Protein 2 BCL2-Binding Protein Bcl2-Binding Protein Bbp
Location (GRCh38)
1:223779893-223845954
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001031685.3
Sequence length
4632.0 nt
GC content
0.4754

Transcripts

ID Sequence Length GC content
NM_001031685.3 NCBI
GGUUUCGGAGCGGAGGAGGGAGCCCCGACCGUCACGAGCGUCGAAGAGA… 4632 nt 0.4754
NM_005426.3 NCBI
GGUUUCGGAGCGGAGGAGGGAGCCCCGACCGUCACGAGCGUCGAAGAGA… 4764 nt 0.4763
Summary

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human cadavers demonstrated that the TP53BP2 was highly expressed at later postmortem intervals (96 h and 120 h) in prostate tissues, showing significant upregulation in Groups 3 and 4 compared to a 24-hour control, as validated by PCR Array analysis [Tolbert et al. DOI:10.1016/j.gene.2018.06.090].