Basic Information

Symbol
TP73
RNA class
mRNA
Alias
Tumor Protein P73 P73 P53-Like Transcription Factor P53-Related Protein CILD47
Location (GRCh38)
1:3652516-3736201
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005427.4
Sequence length
5192.0 nt
GC content
0.6106

Transcripts

ID Sequence Length GC content
NM_001204191.2 NCBI
GGAUUCAGCCAGUUGACAGAACUAAGGGAGAUGGGAAAAGCGAAAAUGC… 4832 nt 0.6031
NM_001204192.2 NCBI
AAUGUGUGCUGGAAGGUGUCCAGGAAGCCCUGCUAAGCAUCUGUCAGUG… 4953 nt 0.6035
NM_005427.4 NCBI
GCCCUGCCUCCCCGCCCGCGCACCCGCCCGGAGGCUCGCGCGCCCGCGA… 5192 nt 0.6106
Showing 11 to 13 of 13 entries
Summary

This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]

Forensic Context

A study in human cadavers demonstrated that the TP73 was highly expressed at later postmortem intervals (96 h and 120 h) in prostate tissues, indicating its pro-apoptotic role in the thanatotranscriptome [Tolbert et al. DOI:10.1016/j.gene.2018.06.090]. In contrast, an investigation of human liver tissues found the TP73 was down-regulated (-4.1491 fold) in decaying samples compared to a 6-hour control, showing tissue-specific apoptotic gene expression patterns after death [Javan et al. DOI:10.1007/S12024-015-9704-6].