Basic Information

Symbol
TPBG
RNA class
mRNA
Alias
Trophoblast Glycoprotein 5T4 5T4 Oncofetal Trophoblast Glycoprotein Wnt-Activated Inhibitory Factor 1 5T4 Oncotrophoblast Glycoprotein 5T4 Oncofetal Antigen 5T4-AG WAIF1 M6P1 5T4AG
Location (GRCh38)
6:82363206-82367420
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001376922.1
Sequence length
2890.0 nt
GC content
0.5135

Transcripts

ID Sequence Length GC content
NM_001166392.2 NCBI
ACCCGGAGGCCGACCUUCCGCCGAGGCGGUGCAGGAAGGAACGGGAGAG… 2884 nt 0.5114
NM_001376922.1 NCBI
GCGAAGAGAGUCGGCGCCCGCAACGCGGAGCCGGGAAGUCGUCGCUACU… 2890 nt 0.5135
NM_006670.5 NCBI
ACUCCUCAUCCUUGGAGCUUUCUCCACAGAAGUGACUUGACACACCGCG… 3618 nt 0.5182
Summary

This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

Forensic Context

A single-cell transcriptomic analysis in a rat model of radiation-induced lung injury identified the TPBG as an orthologous rat gene associated with inflammatory processes [Shi et al. DOI:10.17305/bb.2024.10357].