Basic Information

Symbol
TPCN2
RNA class
mRNA
Alias
Two Pore Segment Channel 2 TPC2 Two Pore Calcium Channel Protein 2 Two Pore Channel Protein 2 Voltage-Dependent Calcium Channel Protein TPC2 SHEP10
Location (GRCh38)
11:69048850-69136316
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_139075.4
Sequence length
4969.0 nt
GC content
0.5569

Transcripts

ID Sequence Length GC content
NM_139075.4 NCBI
GCAGUGAAGCUGGGCGCCUUCGGGGCUUGAGCUUCUGAGGGUCGGGUCC… 4969 nt 0.5569
Summary

This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]

Forensic Context

A study in mice demonstrated that the TPCN2 was significantly upregulated (2.28-fold) in injured dorsal root ganglia following spinal nerve ligation, as identified through strand-specific RNA sequencing and validated by quantitative real-time PCR [Wu et al. DOI:10.1177/1744806916629048].