Basic Information

Symbol
TPGS2
RNA class
mRNA
Alias
Tubulin Polyglutamylase Complex Subunit 2 PGs2 C18orf10 Polyglutamylase Subunit 2 DKFZP586M1523 HsT3006 Chromosome 18 Open Reading Frame 10 HMFN0601 L17
Location (GRCh38)
18:36777647-36829216
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015476.4
Sequence length
3835.0 nt
GC content
0.4639

Transcripts

ID Sequence Length GC content
NM_001271949.2 NCBI
GCGAAGGGGAAGCUACGUCCCGGAGGUGCGGUGUGGGGCACCGGGCGGG… 3730 nt 0.4635
NM_001271950.2 NCBI
GCGAAGGGGAAGCUACGUCCCGGAGGUGCGGUGUGGGGCACCGGGCGGG… 3706 nt 0.4633
NM_001271951.2 NCBI
GCGAAGGGGAAGCUACGUCCCGGAGGUGCGGUGUGGGGCACCGGGCGGG… 1463 nt 0.5215
NM_001271952.2 NCBI
GCGAAGGGGAAGCUACGUCCCGGAGGUGCGGUGUGGGGCACCGGGCGGG… 1392 nt 0.5172
NM_001271953.2 NCBI
GCGAAGGGGAAGCUACGUCCCGGAGGUGCGGUGUGGGGCACCGGGCGGG… 1302 nt 0.5315
NM_001271954.2 NCBI
GCGAAGGGGAAGCUACGUCCCGGAGGUGCGGUGUGGGGCACCGGGCGGG… 1323 nt 0.5253
NM_001271955.2 NCBI
GCGAAGGGGAAGCUACGUCCCGGAGGUGCGGUGUGGGGCACCGGGCGGG… 1188 nt 0.5253
NM_001271956.2 NCBI
GCGAAGGGGAAGCUACGUCCCGGAGGUGCGGUGUGGGGCACCGGGCGGG… 1057 nt 0.5449
NM_001330572.2 NCBI
GCGAAGGGGAAGCUACGUCCCGGAGGUGCGGUGUGGGGCACCGGGCGGG… 2129 nt 0.4847
NM_015476.4 NCBI
GCGAAGGGGAAGCUACGUCCCGGAGGUGCGGUGUGGGGCACCGGGCGGG… 3835 nt 0.4639
Summary

This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]

Forensic Context

A study in humans demonstrated that the TPGS2 was downregulated in subcutaneous adipose tissue during short-term (0-5 month) weight loss in obese participants [Bollepalli et al. DOI:10.1038/ijo.2017.245].