Basic Information

Symbol
TPI1
RNA class
mRNA
Alias
Triosephosphate Isomerase 1 Triose-Phosphate Isomerase Triosephosphate Isomerase Methylglyoxal Synthase EC 5.3.1.1 TIM TPI Epididymis Secretory Protein Li 49 EC 4.2.3.3 HEL-S-49 TPID
Location (GRCh38)
12:6867119-6870948
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000365.6
Sequence length
1351.0 nt
GC content
0.5403

Transcripts

ID Sequence Length GC content
NM_000365.6 NCBI
GCAGACACUGACCUUCAGCGCCUCGGCUCCAGCGCCAUGGCGCCCUCCA… 1351 nt 0.5403
NM_001159287.1 NCBI
GGGCGGGGGGCAGGGCUCCGGGGGACUGGGCGGGCCAUGGCGGAGGACG… 1460 nt 0.5555
NM_001258026.2 NCBI
CUCCCCUUCCUCGCCGGCGUCCGCGUCCCCGCGCCGAGCUGCUCGGGCU… 1605 nt 0.5495
Summary

This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

Forensic Context

A study in humans demonstrated that the TPI1 is a DNA methylation marker for venous blood identification, showing a high methylation indicative value in venous and menstrual blood [Lin et al. DOI:10.1007/S12024-016-9763-3]. Separately, research in human trauma patients identified the TPI1 as an RNA transcript important for predicting multiple organ failure, where it was part of a 16-transcript panel derived from early blood samples that achieved high predictive accuracy [Duran et al. DOI:10.1186/s13613-024-01364-5].