Basic Information

Symbol
TPM1
RNA class
mRNA
Alias
Tropomyosin 1 C15orf13 Cardiomyopathy, Hypertrophic 3 Tropomyosin Alpha-1 Chain CMH3 TMSA Chromosome 15 Open Reading Frame 13 Epididymis Secretory Protein Li 265 Sarcomeric Tropomyosin Kappa Tropomyosin 1 (Alpha) Alpha-Tropomyosin Tropomyosin-1 HEL-S-265 HTM-Alpha CMD1Y LVNC9
Location (GRCh38)
15:63042481-63071915
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001018005.2
Sequence length
1217.0 nt
GC content
0.5094

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-385.4 kcal/mol
Thermodynamic ensemble
Free energy: -407.14 kcal/mol
Frequency: 0.0000
Diversity: 372.51
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((....((((((((((.((.((.(((.((((((((...)).((....))..((((....(((((((((.((((((((..(.((...((.(((........)))))...((((..((((((((((((......)))))..))))))).))))(((....)))..)).)..))))))))....(((..(((..(((((........))))).)))..)))..............(((((((...(((((.((...((....((((...(((((((.....((((((......)))).))((((..........))))......(((..(((..(.((((((((.....(((((((.(((.(((((((.((......)).))))).))...))))))))))....(((((((...)))))))..)))))))).)..)))..))).)))))))...))))...))..)))))))..).))...))))..................(((...(((((.........))))).....)))((((...)))).....(((.....)))........)))).)))))....)))).(((....)))))))).).)))..)).)).)))))))))).)))))....((((((((..((((((..((((.(((..............(((((............))))).(((.(((.(((..(((((.((....(((..(((((((((((....(((((.(((....))).)))))..((((((.(.(((((.((.(((((.((((((((((..((((((((((((......)))).....(((((..((.((((((((((..(((((((((..((((...)))).))))).......((((.....))))......))))(((......)))))))....))))))))..))))).))))))))..))))))........)))).)).))).))))))).).)))).)).))))))))....)))..)))....)).)))))..))).))).)))...))).))))..)))))).....))))))))........(((((.(((.((..((((((.......)))))).((((((.......))))))...............(((((((((((.((....)).))))...)))))))....)).)))..))))).......
Thermodynamic Ensemble Prediction
{{{{...{{,({((({(((((((,{.{{{,{{{,{{((((,({,(({.,.,,.|,|||....}|||....|}||||{{((,...})).,||((((........))))}...{(((..((((((((((((......)))))..))))))).)))}))))),)|||,.......)))))))).,}..,}))))(((((((({({{({.(((({((((((.{(,.............}}))))))...,.{{..((((.......(((((((((.......((((((((((...((((((((,((((..........)))}.....,||,..(((..(.(((((((({{,..(((((((.(((.(((((((.((......)).))))).))...)))))))))).,..(((((((...))))))),})))))))).)..))).((((((((((((.(((((((..{{,..,|}}|(((((((..(((((..................{((...{((((.....,,..}}}}}.,,{{|||(((,...|||}......(({.,{{.|.........,.))})))},,,..}}})}))})).,}.,}.((..((((.......))).)..)))))))..))))))),..((({....)))).(((((((.(,.,...........(((((............))))).{{{{,||,.{{..(((((((....{{{{,,((({{{(,,,{(((,(({{((({,{..{({((,((((,.,,{((({{..,,({{(..,{{||||.{|{|||}||||||||||{{,.,.......,{{{,{,,,,{{{.,{{,||||||,..|,,,.{|||||{,,||||...)))).))}),.})}}.}}}}|..|||}|.)},,}..)})))}.......,,.})))),)))},)))))}}))),,.}}))))))}.,},))))})).)})))))||,..,}},.)))))))..))))).))))))),,...))))))))...)))))............))))).,))))))))))))),|,,...((((((........)))))).})))).)).}}}|(((((,....,.}}}}}}.((((((.......))))))..........,....,,,||||||||,,},.{{{{{{{{....)))},,,,}}},...))))))))........

Transcripts

ID Sequence Length GC content
NM_000366.6 NCBI
GCUCGCACUCCCGCUCCUCCGCCCGACCGCGCGCUCGCCCCGCCGCUCC… 1265 nt 0.5067
NM_001018004.2 NCBI
GCUCGCACUCCCGCUCCUCCGCCCGACCGCGCGCUCGCCCCGCCGCUCC… 1681 nt 0.4759
NM_001018005.2 NCBI
GCUCGCACUCCCGCUCCUCCGCCCGACCGCGCGCUCGCCCCGCCGCUCC… 1217 nt 0.5094
NM_001018006.2 NCBI
GCUCGCACUCCCGCUCCUCCGCCCGACCGCGCGCUCGCCCCGCCGCUCC… 1681 nt 0.4741
NM_001018007.2 NCBI
GCUCGCACUCCCGCUCCUCCGCCCGACCGCGCGCUCGCCCCGCCGCUCC… 1681 nt 0.4902
NM_001018008.2 NCBI
AGCCAGGACAGCCGCGGCAGCCGGGUCCGCAGGGCAGCAGCCGGCCUCU… 2797 nt 0.4458
NM_001018020.2 NCBI
GCUCGCACUCCCGCUCCUCCGCCCGACCGCGCGCUCGCCCCGCCGCUCC… 1681 nt 0.4884
NM_001301244.2 NCBI
GCUCGCACUCCCGCUCCUCCGCCCGACCGCGCGCUCGCCCCGCCGCUCC… 1217 nt 0.5292
NM_001301289.2 NCBI
AGCCAGGACAGCCGCGGCAGCCGGGUCCGCAGGGCAGCAGCCGGCCUCU… 1577 nt 0.4845
NM_001330344.2 NCBI
AGCCAGGACAGCCGCGGCAGCCGGGUCCGCAGGGCAGCAGCCGGCCUCU… 1577 nt 0.4826
Showing 1 to 10 of 40 entries
Summary

This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy and dilated cardiomyopathy 1Y. [provided by RefSeq, Jun 2022]

Forensic Context

A review of proteomics in forensic science notes that the TPM1 is a protein marker for post-mortem interval (PMI) estimation in early PMI from skeletal muscle in humans and animal models, where its abundance decreases post-mortem [Alex et al. DOI:10.1016/j.scijus.2025.101320]. A study in mice demonstrated that the TPM1 is a tissue-specific target and the most expressed gene in mouse femoral quadriceps and cardiac muscle [Scrivano et al. DOI:10.1007/s00414-019-02125-x]. In a separate investigation using a heart-specific double knockout mouse model, immunoblotting revealed the TPM1 protein level was unchanged in the genetically modified hearts [Lee et al. DOI:10.1093/hmg/ddac108].