Basic Information

Symbol
TPM2
RNA class
mRNA
Alias
Tropomyosin 2 NEM4 DA1 Nemaline Myopathy Type 4 Tropomyosin Beta Chain Tropomyosin 2 (Beta) AMCD1 TMSB Arthrogryposis Multiplex Congenital, Distal, Type 1 Epididymis Secretory Protein Li 273 Beta-Tropomyosin Tropomyosin-2 HEL-S-273 CMYO23 CMYP23 DA2B4 DA2B
Location (GRCh38)
9:35681992-35690056
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003289.4
Sequence length
1190.0 nt
GC content
0.5773

Transcripts

ID Sequence Length GC content
NM_001301226.2 NCBI
AGUCCCGCUCCGUCCUCCUCGCCUGCCACCGGUGCACCCAGUCCGCUCA… 1036 nt 0.5840
NM_001301227.2 NCBI
AGUCCCGCUCCGUCCUCCUCGCCUGCCACCGGUGCACCCAGUCCGCUCA… 1190 nt 0.5849
NM_003289.4 NCBI
AGUCCCGCUCCGUCCUCCUCGCCUGCCACCGGUGCACCCAGUCCGCUCA… 1190 nt 0.5773
NM_213674.1 NCBI
GCGGCCGCACCCCCCGGCCGGGCCGUGCUUCUGCCCCUACAAGGUUUGG… 1182 nt 0.6117
Summary

This gene encodes beta-tropomyosin, a member of the actin filament binding protein family, and mainly expressed in slow, type 1 muscle fibers. Mutations in this gene can alter the expression of other sarcomeric tropomyosin proteins, and cause cap disease, nemaline myopathy and distal arthrogryposis syndromes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Forensic Context

A study in human and rat corpus cavernosum identified the TPM2 as a gene associated with principal components of spatially variable genes in endothelial cells, showing a close relationship with energy metabolism and higher expression in specific regions [Yin et al. DOI:10.1016/j.celrep.2024.114760]. In a separate human bioinformatics analysis, the TPM2 was utilized as a marker for manual annotation of vascular smooth muscle cell clusters in a carotid atherosclerosis dataset [Xue et al. DOI:10.3233/JAD-230559].