Basic Information

Symbol
TPM4
RNA class
mRNA
Alias
Tropomyosin 4 Tropomyosin Alpha-4 Chain TM30p1 Epididymis Secretory Protein Li 108 Tropomyosin-4 HEL-S-108 BDPLT25
Location (GRCh38)
19:16067021-16103011
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_003290.3
Sequence length
2474.0 nt
GC content
0.4697

Transcripts

ID Sequence Length GC content
NM_001145160.2 NCBI
ACUCUGCCCCACAGCCACAGCCCCUGACUGCCGCAGCCCCCACAGAGCC… 2598 nt 0.4665
NM_001367836.1 NCBI
ACUCUGCCCCACAGCCACAGCCCCUGACUGCCGCAGCCCCCACAGAGCC… 2822 nt 0.4826
NM_001367837.2 NCBI
GUGCAGCUCUCGCCGGAGCCGAGCCCAGCCGAGCGUCCGCCGCUGCCCG… 2216 nt 0.5221
NM_001367838.1 NCBI
GUAUCGUGCAGGCUCCGACUCCGGGGCUGGCGCCGGGGUCCCGGGCCGA… 2547 nt 0.4574
NM_003290.3 NCBI
GUGCAGCUCUCGCCGGAGCCGAGCCCAGCCGAGCGUCCGCCGCUGCCCG… 2474 nt 0.4697
Summary

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Forensic Context

A study in human pediatric sepsis patients demonstrated that the TPM4 exhibited robustly increased polyadenylation in viral compared to bacterial infection samples, as confirmed via bootstrapping sensitivity analysis [He et al. DOI:10.1186/s12879-025-11078-z].