Enables signaling receptor activity. Contributes to peptide antigen binding activity. Involved in T cell activation involved in immune response; T cell mediated cytotoxicity directed against tumor cell target; and detection of tumor cell. Located in cell surface. Part of alpha-beta T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]
A study in mice demonstrated that in a closed head injury model, the transcript marker for T-cells, the TRA, did not show altered expression in response to trauma in any animals at the examined post-injury time points [Israelsson et al. DOI:10.1089/neu.2008.0676].