Basic Information

Symbol
TRA2A
RNA class
mRNA
Alias
Transformer 2 Alpha Homolog AWMS1 Transformer-2 Protein Homolog Alpha Transformer-2 Protein Homolog A Htra-2-Alpha TRA-2 Alpha TRA2-Alpha Transformer 2 Alpha Homolog (Drosophila) Putative MAPK Activating Protein PM24 Transformer-2 Alpha Htra-2 Alpha Tra2alpha HSU53209
Location (GRCh38)
7:23504780-23532041
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_013293.5
Sequence length
1785.0 nt
GC content
0.4101

Transcripts

ID Sequence Length GC content
NM_001282757.2 NCBI
AUUUUGCUGGAGCCUGCGACCGAGUGGGAGUGGAGUGGAGCGGCUGUGG… 2086 nt 0.3945
NM_001282758.2 NCBI
AUUUUGCUGGAGCCUGCGACCGAGUGGGAGUGGAGUGGAGCGGCUGUGG… 1875 nt 0.4181
NM_001282759.2 NCBI
AUUUUGCUGGAGCCUGCGACCGAGUGGGAGUGGAGUGGAGCGGCUGUGG… 2173 nt 0.4022
NM_001362759.2 NCBI
AUUUUGCUGGAGCCUGCGACCGAGUGGGAGUGGAGUGGAGCGGCUGUGG… 1596 nt 0.4066
NM_001362760.2 NCBI
AUUUUGCUGGAGCCUGCGACCGAGUGGGAGUGGAGUGGAGCGGCUGUGG… 2097 nt 0.3934
NM_001362761.2 NCBI
AUUUUGCUGGAGCCUGCGACCGAGUGGGAGUGGAGUGGAGCGGCUGUGG… 2377 nt 0.3875
NM_013293.5 NCBI
AUUUUGCUGGAGCCUGCGACCGAGUGGGAGUGGAGUGGAGCGGCUGUGG… 1785 nt 0.4101
Summary

This gene is a member of the transformer 2 homolog family and encodes a protein with several RRM (RNA recognition motif) domains. This phosphorylated nuclear protein binds to specific RNA sequences and plays a role in the regulation of pre-mRNA splicing. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]

Forensic Context

A study in humans demonstrated that transcriptome organization in postmortem prefrontal cortex is associated with lifetime alcohol consumption, with coexpression networks enriched for neurophysiological targets and genome-wide association signals for alcohol dependence [Farris et al. DOI:10.1038/Mp.2014.159].