Basic Information

Symbol
TRA2B
RNA class
mRNA
Alias
Transformer 2 Beta Homolog Htra2-Beta PPP1R156 SFRS10 Splicing Factor, Arginine/Serine-Rich 10 (Transformer 2 Homolog, Drosophila) Protein Phosphatase 1, Regulatory Subunit 156 Transformer-2 Protein Homolog Beta Transformer-2 Protein Homolog B TRA-2 Beta Splicing Factor, Arginine/Serine-Rich 10 Transformer 2 Beta Homolog (Drosophila) HTRA2-Beta TRA2-BETA TRA2-Beta SRFS10 TRAN2B
Location (GRCh38)
3:185914558-185938103
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004593.3
Sequence length
4178.0 nt
GC content
0.4095

Transcripts

ID Sequence Length GC content
NM_001243879.2 NCBI
AGAGCCCGUGCGGAGGCGGUGCGGAGCAUUUCGGCUCUGAGCGGCUGGG… 4044 nt 0.4053
NM_004593.3 NCBI
AGAGCCCGUGCGGAGGCGGUGCGGAGCAUUUCGGCUCUGAGCGGCUGGG… 4178 nt 0.4095
Summary

This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Forensic Context

A study in mice demonstrated that chronic ethanol exposure drastically induced the TRA2B in AML-12 hepatocytes and mouse livers, where it promoted ethanol-induced fat accumulation by down-regulating SIRT1 [Yin et al. DOI:10.1074/Jbc.M111.333534].