Basic Information

Symbol
TRABD2A
RNA class
mRNA
Alias
TraB Domain Containing 2A TIKI1 C2orf89 TRAB Domain-Containing Protein 2A Metalloprotease TIKI1 Chromosome 2 Open Reading Frame 89 UPF0632 Protein C2orf89 EC 3.4.-.-
Location (GRCh38)
2:84821650-84907008
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001277053.2
Sequence length
1814.0 nt
GC content
0.5573

Transcripts

ID Sequence Length GC content
NM_001080824.3 NCBI
ACUCCUUCCCUCCGCGUUCCGGGCCUCGGAGCCGCCUUGAGGAGGAUGA… 1667 nt 0.5573
NM_001277053.2 NCBI
ACUCCUUCCCUCCGCGUUCCGGGCCUCGGAGCCGCCUUGAGGAGGAUGA… 1814 nt 0.5573
NM_001307978.2 NCBI
ACUCCUUCCCUCCGCGUUCCGGGCCUCGGAGCCGCCUUGAGGAGGAUGA… 3359 nt 0.4412
Summary

Enables Wnt-protein binding activity and metalloendopeptidase activity. Involved in negative regulation of Wnt signaling pathway and proteolysis. Located in organelle membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the TRABD2A as a laminar marker for layer 5 in the dorsolateral prefrontal cortex for spatial transcriptomics [Yang et al. DOI:10.1007/s00414-022-02889-9]. In a separate human study, the TRABD2A was investigated as a candidate mRNA for predicting the time-of-day of bloodstain deposition, where it was removed from the final analysis dataset due to high correlation with other markers [Gosch et al. DOI:10.1101/2025.02.03.636230].