Basic Information

Symbol
TRAF1
RNA class
mRNA
Alias
TNF Receptor Associated Factor 1 EBI6 TNF Receptor-Associated Factor 1 Epstein-Barr Virus-Induced Protein 6 Epstein-Bar Virus-Induced Protein 6 MGC:10353
Location (GRCh38)
9:120902393-120931875
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005658.5
Sequence length
4351.0 nt
GC content
0.5539

Transcripts

ID Sequence Length GC content
NM_001190945.2 NCBI
ACUCCACCGGAAGCUCCGGGCCUGGCCGCCGGUAGGCGGUGGCGGAGGC… 4301 nt 0.5582
NM_001190947.2 NCBI
AGAGAGUGAGUGAUGAUUACGGAGCUGUGUGGACUGUGCCCUGACAGGA… 3726 nt 0.5537
NM_005658.5 NCBI
GAUUUCAUCAGGGCUUUCCUGCUCCUUCUGGUUGCCUCAGUCCCAGGCA… 4351 nt 0.5539
Summary

The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Forensic Context

A study in human primary lung microvascular endothelial cells demonstrated that exposure to 10 Gy X-irradiation induced a significant transcriptional upregulation of the TRAF1 gene, with a 7.2-fold increase in mRNA expression at 24 hours post-irradiation as determined by RNA-seq analysis [Bouten et al. DOI:10.1038/s41598-021-03636-7]. This finding was part of a broader integrated response involving DNA damage, cell cycle arrest, senescence, and pro-inflammatory signaling, where the TRAF1 was identified within the context of anti-apoptotic TNF signaling pathways.