Basic Information

Symbol
TRAF3
RNA class
mRNA
Alias
TNF Receptor Associated Factor 3 CAP-1 CRAF1 LAP1 CD40bp RNF118 RING-Type E3 Ubiquitin Transferase TRAF3 TNF Receptor-Associated Factor 3 LMP1-Associated Protein 1 CD40 Receptor Associated Factor 1 CD40 Receptor-Associated Factor 1 CD40 Associated Protein 1 CD40 Binding Protein CD40-Binding Protein EC 2.3.2.27 IMD132A IMD132B TRAFAMN CD40BP IIAE5 CAP1
Location (GRCh38)
14:102777326-102911500
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_145725.3
Sequence length
7806.0 nt
GC content
0.5452

Transcripts

ID Sequence Length GC content
NM_001199427.2 NCBI
GCGGGGCUGCGUGAGGGAGCGAGGGAGCGAGGGAGCGCGGCGCGGCCGC… 7418 nt 0.5449
NM_001385142.1 NCBI
GCGGGGCUGCGUGAGGGAGCGAGGGAGCGAGGGAGCGCGGCGCGGCCGC… 7665 nt 0.5494
NM_001385143.1 NCBI
GCGGGGCUGCGUGAGGGAGCGAGGGAGCGAGGGAGCGCGGCGCGGCCGC… 7725 nt 0.5446
NM_003300.4 NCBI
GCGGGGCUGCGUGAGGGAGCGAGGGAGCGAGGGAGCGCGGCGCGGCCGC… 7667 nt 0.5457
NM_145725.3 NCBI
GCGGGGCUGCGUGAGGGAGCGAGGGAGCGAGGGAGCGCGGCGCGGCCGC… 7806 nt 0.5452
NM_145726.3 NCBI
GCGGGGCUGCGUGAGGGAGCGAGGGAGCGAGGGAGCGCGGCGCGGCCGC… 7731 nt 0.5457
Summary

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]

Forensic Context

A study in mice demonstrated that the proportion of CAP-1 positive monocytes was higher in the sepsis group compared to controls [Li et al. DOI:10.1016/j.intimp.2024.111938].