Basic Information

Symbol
TRAF5
RNA class
mRNA
Alias
TNF Receptor Associated Factor 5 RNF84 TNF Receptor-Associated Factor 5 RING Finger Protein 84 MGC:39780
Location (GRCh38)
1:211326325-211375036
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001033910.3
Sequence length
3976.0 nt
GC content
0.4188

Transcripts

ID Sequence Length GC content
NM_001033910.3 NCBI
AGGAGCAGCAGCCGCGCCUGCAGACCGGCCUCGCGGAGCCCGCGCGCCG… 3976 nt 0.4188
NM_001319207.2 NCBI
AGGAGCAGCAGCCGCGCCUGCAGACCGGCCUCGCGGAGCCCGCGCGCCG… 4009 nt 0.4198
NM_004619.4 NCBI
AGAUGACUGGACUUGUAGAUACUAACGGUUCUGAAGCGGAAUGGCUUAU… 3958 nt 0.4136
NM_145759.3 NCBI
AGUGCAGGGAUGUGCAGAUGAGUGGGCUGUGGGGUGUCCUGCUCACGGU… 3978 nt 0.4155
Summary

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

Forensic Context

A study in humans analyzing single-cell and bulk RNA-sequencing data from sepsis patients' peripheral blood mononuclear cells identified the IL-17 signaling pathway as a key mechanism, with pathway-associated genes including TRAF5 being significantly up-regulated in sepsis blood samples compared to healthy controls [Zhao et al. DOI:10.1016/j.imbio.2023.152763].