Basic Information

Symbol
TRDMT1
RNA class
mRNA
Alias
TRNA Aspartic Acid Methyltransferase 1 TRNA (Cytosine(38)-C(5))-Methyltransferase RNMT1 DNMT2 DNA (Cytosine-5)-Methyltransferase-Like Protein 2 DNA MTase Homolog HsaIIP DNA (Cytosine-5-)-Methyltransferase 2 TRNA (Cytosine-5-)-Methyltransferase DNA Methyltransferase Homolog HsaIIP DNA Cytosine-5 Methyltransferase 2 DNA Methyltransferase-2 EC 2.1.1.204 EC 2.1.1.29 M.HsaIIP EC 2.1.1 MHSAIIP DMNT2 PUMET Dnmt2 PuMet
Location (GRCh38)
10:17137336-17202054
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004412.7
Sequence length
12918.0 nt
GC content
0.3838

Transcripts

ID Sequence Length GC content
NM_001321006.2 NCBI
AGGCCUAGCUCCGGGGCUGCGGCGGCUGAGGCGCGGGGAUGGAGCCCCU… 12775 nt 0.3843
NM_001321007.2 NCBI
AGGCCUAGCUCCGGGGCUGCGGCGGCUGAGGCGCGGGGAUGGAGCCCCU… 13148 nt 0.3833
NM_001351219.2 NCBI
AGGCCUAGCUCCGGGGCUGCGGCGGCUGAGGCGCGGGGAUGGAGCCCCU… 12897 nt 0.3836
NM_001351220.2 NCBI
AGGCCUAGCUCCGGGGCUGCGGCGGCUGAGGCGCGGGGAUGGAGCCCCU… 2492 nt 0.3684
NM_001351221.2 NCBI
AGGCCUAGCUCCGGGGCUGCGGCGGCUGAGGCGCGGGGAUGGAGCCCCU… 12759 nt 0.3840
NM_001351222.2 NCBI
AGGCCUAGCUCCGGGGCUGCGGCGGCUGAGGCGCGGGGAUGGAGCCCCU… 2701 nt 0.3658
NM_001351223.2 NCBI
AGGCCUAGCUCCGGGGCUGCGGCGGCUGAGGCGCGGGGAUGGAGCCCCU… 2538 nt 0.3664
NM_004412.7 NCBI
AGGCCUAGCUCCGGGGCUGCGGCGGCUGAGGCGCGGGGAUGGAGCCCCU… 12918 nt 0.3838
Summary

This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]

Forensic Context

The provided literature, a review article, discusses Dnmt2 as an RNA methyltransferase homologous to DNA methyltransferases, noting its role in the development of the brain and other organs and its requirement for retrotransposon silencing in Drosophila somatic cells [Mattick DOI:10.1002/bies.201000028].