Basic Information

Symbol
TREM1
RNA class
mRNA
Alias
Triggering Receptor Expressed On Myeloid Cells 1 TREM-1 CD354 Triggering Receptor Expressed On Monocytes 1 CD354 Antigen
Location (GRCh38)
6:41267100-41286682
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_018643.5
Sequence length
3252.0 nt
GC content
0.4917

Transcripts

ID Sequence Length GC content
NM_001242589.3 NCBI
AGCAGUUGGAGCUGGUGCACAGGAAGGAUGAGGAAGACCAGGCUCUGGG… 2050 nt 0.4220
NM_001242590.3 NCBI
AGCAGUUGGAGCUGGUGCACAGGAAGGAUGAGGAAGACCAGGCUCUGGG… 3059 nt 0.4920
NM_018643.5 NCBI
AGCAGUUGGAGCUGGUGCACAGGAAGGAUGAGGAAGACCAGGCUCUGGG… 3252 nt 0.4917
Summary

This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

Forensic Context

A study in mice demonstrated that the TREM1 is a plasma protein biomarker significantly elevated in Subclass 1 pediatric septic shock patients, who exhibit worse clinical outcomes, compared to Subclass 2 [Yang et al. DOI:10.1186/s13054-023-04689-y]. In a separate investigation using human and rat models of UVB-induced inflammatory pain, the TREM1 was identified as an up-regulated gene in skin, with a fold change of 14.4 in human and 17.6 in rat skin, indicating its role in the amplification of inflammation [Dawes et al. DOI:10.1371/journal.pone.0093338].