Basic Information

Symbol
TREM2
RNA class
mRNA
Alias
Triggering Receptor Expressed On Myeloid Cells 2 TREM-2 Trem2a Trem2b Trem2c Triggering Receptor Expressed On Myeloid Cells 2a Triggering Receptor Expressed On Monocytes 2 PLOSL2 AD17
Location (GRCh38)
6:41158488-41163186
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_018965.4
Sequence length
983.0 nt
GC content
0.5788

Transcripts

ID Sequence Length GC content
NM_001271821.2 NCBI
ACUCUGCUUCUGCCCUUGGCUGGGGAAGGGUGGCAUGGAGCCUCUCCGG… 789 nt 0.5792
NM_018965.4 NCBI
ACUCUGCUUCUGCCCUUGGCUGGGGAAGGGUGGCAUGGAGCCUCUCCGG… 983 nt 0.5788
Summary

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Forensic Context

A study in human datasets identified the TREM2 as a marker for microglia activation in Alzheimer's disease, with its soluble form (sTREM2) found at elevated levels in the cerebrospinal fluid and peripheral blood of AD patients compared to normal controls [Xue et al. DOI:10.3233/JAD-230559].