Basic Information

Symbol
TRH
RNA class
mRNA
Alias
Thyrotropin Releasing Hormone Prothyroliberin Pro-Thyrotropin-Releasing Hormone Pro-TRH Thyrotropin-Releasing Hormone Thyrotropin-Releasing Factor TSH-Releasing Factor Protirelin TRF
Location (GRCh38)
3:129974688-129977935
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_007117.5
Sequence length
1560.0 nt
GC content
0.5968

Transcripts

ID Sequence Length GC content
NM_007117.5 NCBI
CGGCAGGCGCCCGGGGUCCUCAGCGCUGCAGACUCCUGACCUGCCGACU… 1560 nt 0.5968
Summary

This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]

Forensic Context

A study in mice demonstrated that UVB irradiation induces significant differential expression of specific tRNA-derived fragments (tRFs) and tRNA-derived stress-induced RNAs (tiRNAs) in skin tissue [Fang et al. DOI:10.3389/fcell.2021.707572].