Basic Information

Symbol
TRIB1
RNA class
mRNA
Alias
Tribbles Pseudokinase 1 C8FW GIG2 TRB1 G-Protein-Coupled Receptor-Induced Gene 2 Protein Tribbles Homolog 1 GIG-2 SKIP1 TRB-1 Phosphoprotein Regulated By Mitogenic Pathways G-Protein-Coupled Receptor-Induced Protein 2 G-Protein-Coupled Receptor Induced Protein Tribbles Homolog 1 (Drosophila) Tribbles-Like Protein 1
Location (GRCh38)
8:125430358-125438403
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_025195.4
Sequence length
3596.0 nt
GC content
0.5239

Transcripts

ID Sequence Length GC content
NM_001282985.2 NCBI
CUACUGCCCAACCCGAAUGAAAUUUCAGACGCAUGAUCAAGCCCAGUUU… 2807 nt 0.4564
NM_025195.4 NCBI
ACACUCACUCACAGUCACUCUCUCUGAGCGCGUCUCGCUCGCUCUCAUA… 3596 nt 0.5239
Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; mitogen-activated protein kinase kinase binding activity; and protein kinase inhibitor activity. Involved in several processes, including JNK cascade; negative regulation of lipopolysaccharide-mediated signaling pathway; and regulation of protein kinase activity. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in humans demonstrated that the TRIB1 exhibits statistically significant rhythmic expression in blood, with peak expression occurring in the afternoon (15:30-17:00 h), and was identified as a candidate mRNA marker for estimating blood deposition time [Lech et al. DOI:10.1016/J.Fsigen.2015.12.008]. A subsequent study in a Chinese Han population selected the TRIB1 as a candidate biomarker based on literature, though its rhythmic expression results were not reported in the experimental findings [Cheng et al. DOI:10.1016/J.Fsigen.2023.102910].