Basic Information

Symbol
TRIM13
RNA class
mRNA
Alias
Tripartite Motif Containing 13 RNF77 Ret Finger Protein 2 DLEU5 Leu5 RFP2 B-Cell Chronic Lymphocytic Leukemia Tumor Suppressor Leu5 RING-Type E3 Ubiquitin Transferase TRIM13 Tripartite Motif-Containing Protein 13 E3 Ubiquitin-Protein Ligase TRIM13 Putative Tumor Suppressor RFP2 Leukemia-Associated Protein 5 RING Finger Protein 77 Tripartite Motif-Containing 13 Tripartite Motif Protein 13 CLL-Associated RING Finger EC 2.3.2.27 LEU5 CAR
Location (GRCh38)
13:49995888-50020481
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_213590.3
Sequence length
7255.0 nt
GC content
0.3920

Transcripts

ID Sequence Length GC content
NM_001007278.3 NCBI
GAGUCCAUUUUGGGGCUGUGCUUGGCGCGUACCGUGCGGUCCCUGUAGU… 6919 nt 0.3821
NM_005798.5 NCBI
GAGUCCAUUUUGGGGCUGUGCUUGGCGCGUACCGUGCGGUCCCUGUAGU… 6720 nt 0.3747
NM_052811.4 NCBI
GAGUCCAUUUUGGGGCUGUGCUUGGCGCGUACCGUGCGGUCCCUGUAGU… 6805 nt 0.3784
NM_213590.3 NCBI
GAGUCCAUUUUGGGGCUGUGCUUGGCGCGUACCGUGCGGUCCCUGUAGU… 7255 nt 0.3920
Summary

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human myocardial samples from explanted hearts demonstrated that the TRIM13 mRNA expression was significantly upregulated in dilated cardiomyopathy (8.16-fold, p < 0.0002) and ischemic cardiomyopathy (4.33-fold, p < 0.002) compared to a healthy control group, while direct sequencing of all seven exons of the gene revealed no mutations in the patient samples [Tatrai et al. DOI:10.1016/J.Forsciint.2011.05.010].