Basic Information

Symbol
TRIM5
RNA class
mRNA
Alias
Tripartite Motif Containing 5 RNF88 TRIM5alpha RING-Type E3 Ubiquitin Transferase TRIM5 Tripartite Motif-Containing Protein 5 Tripartite Motif Protein TRIM5 Tripartite Motif-Containing Protein 5 Alpha Tripartite Motif Protein TRIM Tripartite Motif-Containing 5 Ring Finger Protein 88 RING Finger Protein 88 EC 2.3.2.27 EC 6.3.2
Location (GRCh38)
11:5663195-5938619
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_033034.3
Sequence length
3364.0 nt
GC content
0.4200

Transcripts

ID Sequence Length GC content
NM_001410958.1 NCBI
AAGAAUUUCCUGCGGUUCCUCUAGGAAAAUUCCUUUGUGCAGAUCAGGC… 3082 nt 0.4179
NM_033034.3 NCBI
AAGAAUUUCCUGCGGUUCCUCUAGGAAAAUUCCUUUGUGCAGAUCAGGC… 3364 nt 0.4200
NM_033092.4 NCBI
AAGAAUUUCCUGCGGUUCCUCUAGGAAAAUUCCUUUGUGCAGAUCAGGC… 3591 nt 0.4141
NM_033093.4 NCBI
AAGAAUUUCCUGCGGUUCCUCUAGGAAAAUUCCUUUGUGCAGAUCAGGC… 1961 nt 0.4365
Summary

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

Forensic Context

A study in human cardiac tissue from sudden unexplained death (SUD) and sudden unexpected death in epilepsy (SUDEP) cases identified a differentially methylated region overlapping the TRIM5 gene, distinguishing these groups [Steffan Noe Christiansen et al. DOI:10.3390/ijms22062790].