Basic Information

Symbol
TRIM54
RNA class
mRNA
Alias
Tripartite Motif Containing 54 MURF MURF-3 RNF30 Tripartite Motif-Containing Protein 54 Muscle-Specific RING Finger Protein 3 Ring Finger Protein 30 MuRF3 Muscle-Specific RING Finger Protein Tripartite Motif-Containing 54 RING Finger Protein 30 MuRF-3 MURF3 MuRF
Location (GRCh38)
2:27282366-27309400
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_187841.3
Sequence length
1930.0 nt
GC content
0.5979

Transcripts

ID Sequence Length GC content
NM_032546.4 NCBI
AAACAGUGCUACCCACAGAGUGAACAAGAGAGAGUCAUUUGGGAAACAA… 2056 nt 0.5914
NM_187841.3 NCBI
AAACAGUGCUACCCACAGAGUGAACAAGAGAGAGUCAUUUGGGAAACAA… 1930 nt 0.5979
Summary

The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Forensic Context

A study in rats demonstrated that acute ethanol exposure increased mRNA levels of the TRIM54 in the amygdala, a change validated by qPCR and associated with alcohol-induced anxiolysis [Krishnan et al. DOI:10.1038/S41380-022-01732-2].