Basic Information

Symbol
TRIM55
RNA class
mRNA
Alias
Tripartite Motif Containing 55 MURF-2 RNF29 Tripartite Motif-Containing Protein 55 Muscle-Specific RING Finger Protein 2 Ring Finger Protein 29 MuRF2 Tripartite Motif-Containing 55 Muscle Specific Ring Finger 2 RING Finger Protein 29 EC 2.3.2.27 MuRF-2 MURF2
Location (GRCh38)
8:66126896-66175489
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_184085.2
Sequence length
2679.0 nt
GC content
0.4487

Transcripts

ID Sequence Length GC content
NM_033058.3 NCBI
AGGGCCUGAAACAAUGUCCUCCACCGAGAGAAACGUAAAGGACACUUGA… 2767 nt 0.4463
NM_184085.2 NCBI
AGGGCCUGAAACAAUGUCCUCCACCGAGAGAAACGUAAAGGACACUUGA… 2679 nt 0.4487
NM_184086.2 NCBI
AGGGCCUGAAACAAUGUCCUCCACCGAGAGAAACGUAAAGGACACUUGA… 2391 nt 0.4345
NM_184087.2 NCBI
AGGGCCUGAAACAAUGUCCUCCACCGAGAGAAACGUAAAGGACACUUGA… 1758 nt 0.4306
Summary

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the TRIM55 (Trim55) showed decreased expression with increasing radiation dose, as noted in a discussion comparing findings to prior research in non-survivor pigs [Aryankalayil et al. DOI:10.1080/09553002.2023.2214205].