Basic Information

Symbol
TRIM58
RNA class
mRNA
Alias
Tripartite Motif Containing 58 BIA2 RING-Type E3 Ubiquitin Transferase TRIM58 Tripartite Motif-Containing Protein 58 E3 Ubiquitin-Protein Ligase TRIM58 Tripartite Motif-Containing 58 Protein BIA2 EC 2.3.2.27
Location (GRCh38)
1:247857187-247880138
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mixture deconvolution
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015431.4
Sequence length
5170.0 nt
GC content
0.4803

Transcripts

ID Sequence Length GC content
NM_015431.4 NCBI
GCAGACCGCGAGGGGAGACGGUGCGGGCGGCCGGGAGCGCAGCCCUCCG… 5170 nt 0.4803
Summary

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans developed a target RNA sequencing assay for body fluid mixture deconvolution, where the TRIM58 mRNA contributed the highest read proportions in venous blood but showed cross-reactivity in semen, menstrual blood, and saliva samples [Yu et al. DOI:10.1016/j.fsigen.2025.103416]. The assay, which included microhaplotypes from this marker, demonstrated excellent discriminative capacity in artificial mixtures, successfully detecting all body fluid components and correctly associating most genotypes with their contributors.