Basic Information

Symbol
TRIP12
RNA class
mRNA
Alias
Thyroid Hormone Receptor Interactor 12 ULF E3 Ubiquitin-Protein Ligase For Arf KIAA0045 TRIPC HECT-Type E3 Ubiquitin Transferase TRIP12 E3 Ubiquitin-Protein Ligase TRIP12 TR-Interacting Protein 12 TRIP-12 Probable E3 Ubiquitin-Protein Ligase TRIP12 Thyroid Receptor Interacting Protein 12 Thyroid Receptor-Interacting Protein 12 EC 2.3.2.26 MRD49
Location (GRCh38)
2:229763835-229923239
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001348323.3
Sequence length
10100.0 nt
GC content
0.4204

Transcripts

ID Sequence Length GC content
NM_001284214.2 NCBI
GCUGCGGCUCAGCUGAUAAUUGAAGGAACCCGGAGCCGCCGCCGCCGCG… 10019 nt 0.4202
NM_001284215.2 NCBI
GCUGCGGCUCAGCUGAUAAUUGAAGGAACCCGGAGCCGCCGCCGCCGCG… 9974 nt 0.4204
NM_001284216.2 NCBI
GCUGCGGCUCAGCUGAUAAUUGAAGGAACCCGGAGCCGCCGCCGCCGCG… 9065 nt 0.4139
NM_001348315.2 NCBI
AGAAAGUCCCAGGAAGCCCGGUUGUGUCAUCGCCGCGAUUCGGCCCCCG… 10408 nt 0.4302
NM_001348316.2 NCBI
AGAAAGUCCCAGGAAGCCCGGUUGUGUCAUCGCCGCGAUUCGGCCCCCG… 10070 nt 0.4245
NM_001348317.1 NCBI
GCUGCGGCUCAGCUGAUAAUUGAAGGAACCCGGAGCCGCCGCCGCCGCG… 9959 nt 0.4204
NM_001348318.2 NCBI
AGAAAGUCCCAGGAAGCCCGGUUGUGUCAUCGCCGCGAUUCGGCCCCCG… 10348 nt 0.4305
NM_001348319.1 NCBI
GCUGCGGCUCAGCUGAUAAUUGAAGGAACCCGGAGCCGCCGCCGCCGCG… 10085 nt 0.4204
NM_001348320.2 NCBI
AGAAAGUCCCAGGAAGCCCGGUUGUGUCAUCGCCGCGAUUCGGCCCCCG… 10474 nt 0.4304
NM_001348321.1 NCBI
GCUGCGGCUCAGCUGAUAAUUGAAGGAACCCGGAGCCGCCGCCGCCGCG… 10088 nt 0.4204
Showing 1 to 10 of 26 entries
Summary

The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the ubiquitin-mediated proteolysis pathway in cortical microglia, with the TRIP12 being identified as one of the many components within this pathway that is significantly dysregulated [Oladapo et al. DOI:10.3390/Ijms26020649].