Basic Information

Symbol
TRIP12
RNA class
mRNA
Alias
Thyroid Hormone Receptor Interactor 12 ULF E3 Ubiquitin-Protein Ligase For Arf KIAA0045 TRIPC HECT-Type E3 Ubiquitin Transferase TRIP12 E3 Ubiquitin-Protein Ligase TRIP12 TR-Interacting Protein 12 TRIP-12 Probable E3 Ubiquitin-Protein Ligase TRIP12 Thyroid Receptor Interacting Protein 12 Thyroid Receptor-Interacting Protein 12 EC 2.3.2.26 MRD49
Location (GRCh38)
2:229763835-229923239
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001348323.3
Sequence length
10100.0 nt
GC content
0.4204

Transcripts

ID Sequence Length GC content
NM_001348332.1 NCBI
GCUGCGGCUCAGCUGAUAAUUGAAGGAACCCGGAGCCGCCGCCGCCGCG… 9998 nt 0.4204
NM_001348333.1 NCBI
GCUGCGGCUCAGCUGAUAAUUGAAGGAACCCGGAGCCGCCGCCGCCGCG… 10022 nt 0.4202
NM_001348334.1 NCBI
GGGAGAGACGCUCGAGGGCGGCCGCGGCCGGAGGGACCGGGGCCUGGCG… 5951 nt 0.3920
NM_001348335.2 NCBI
ACCCGCACACUUUCAAUGGGAUAGAAGGGACUCCAAAAGUGAAUGGUAG… 5961 nt 0.3862
NM_001348336.1 NCBI
GCUGCGGCUCAGCUGAUAAUUGAAGGAACCCGGAGCCGCCGCCGCCGCG… 6052 nt 0.3919
NM_004238.3 NCBI
GCUGCGGCUCAGCUGAUAAUUGAAGGAACCCGGAGCCGCCGCCGCCGCG… 9875 nt 0.4201
Showing 21 to 26 of 26 entries
Summary

The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulates the ubiquitin-mediated proteolysis pathway in cortical microglia, with the TRIP12 being identified as one of the many components within this pathway that is significantly dysregulated [Oladapo et al. DOI:10.3390/Ijms26020649].