Basic Information

Symbol
TRIT1
RNA class
mRNA
Alias
TRNA Isopentenyltransferase 1 IPT TRNA Dimethylallyltransferase IPP Transferase Isopentenyl-Diphosphate:TRNA Isopentenyltransferase FLJ20061 IPTase HGRO1 IPPT MOD5 TRNA Dimethylallyltransferase, Mitochondrial TRNA Isopentenylpyrophosphate Transferase EC 2.5.1.75 EC 2.5.1.8 COXPD35 GRO1
Location (GRCh38)
1:39838110-39883511
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_017646.6
Sequence length
5051.0 nt
GC content
0.4225

Transcripts

ID Sequence Length GC content
NM_001312691.1 NCBI
CAAGCGCAGACUGCCAUAAGAUGGCGUCCGUGGCGGCUGCACGAGCAGU… 2081 nt 0.4493
NM_001312692.1 NCBI
CAAGCGCAGACUGCCAUAAGAUGGCGUCCGUGGCGGCUGCACGAGCAGU… 1913 nt 0.4496
NM_017646.6 NCBI
AGACUGCCAUAAGAUGGCGUCCGUGGCGGCUGCACGAGCAGUUCCCGUG… 5051 nt 0.4225
Summary

This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]

Forensic Context

A study in rats demonstrated that temporal expression of wound healing-related genes, including the TRIT1, can inform wound age estimation after skeletal muscle contusion [Du et al. DOI:10.1007/s00414-018-01990-2]. The TRIT1 was one of 14 genes selected in a stepwise Fisher discriminant analysis model, which correctly classified 94.9% of cross-validated grouped cases into post-injury intervals (4–12, 16–24, and 28–48 hours) and showed reasonable predictive validity for estimating injury time.