Basic Information

Symbol
TRMT1
RNA class
mRNA
Alias
TRNA Methyltransferase 1 TRM1 TRNA 2,2-Dimethylguanosine-26 Methyltransferase TRNA(Guanine-26,N(2)-N(2)) Methyltransferase TRNA (Guanine(26)-N(2))-Dimethyltransferase TRNA(M(2,2)G26)Dimethyltransferase FLJ20244 HTRM1 N(2),N(2)-Dimethylguanosine TRNA Methyltransferase TRNA Methyltransferase 1 Homolog (S. Cerevisiae) TRM1 TRNA Methyltransferase 1 Homolog TRNA Methyltransferase 1 Homolog EC 2.1.1.216 EC 2.1.1.32 MRT68
Location (GRCh38)
19:13104899-13117567
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001136035.4
Sequence length
2128.0 nt
GC content
0.6123

Transcripts

ID Sequence Length GC content
NM_001136035.4 NCBI
ACCCACUGUGCCAACAUGGCGGCGCCCAGGUCCUAAUUCGGGAAACGUG… 2128 nt 0.6123
NM_001142554.3 NCBI
ACCCACUGUGCCAACAUGGCGGCGCCCAGGUCCUAAUUCGGGAAACGUG… 2262 nt 0.6136
NM_001351760.2 NCBI
ACCCACUGUGCCAACAUGGCGGCGCCCAGGUCCUAAUUCGGGAAACGUG… 2041 nt 0.6095
NM_001351761.2 NCBI
ACCCACUGUGCCAACAUGGCGGCGCCCAGGUCCUAAUUCGGGAAACGUG… 2037 nt 0.6107
NM_001351762.2 NCBI
ACCCACUGUGCCAACAUGGCGGCGCCCAGGUCCUAAUUCGGGAAACGUG… 2208 nt 0.6137
NM_017722.5 NCBI
ACCCACUGUGCCAACAUGGCGGCGCCCAGGUCCUAAUUCGGGAAACGUG… 2349 nt 0.6160
Summary

This gene encodes a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in this gene have been implicated in autosomal recessive intellectual disorder (ARID). Alternative splicing results in multiple transcript variants encoding different isoforms. There is a pseudogene of this gene on the X chromosome. [provided by RefSeq, May 2017]

Forensic Context

No relevant information is available at the moment.