Basic Information

Symbol
TRMT10A
RNA class
mRNA
Alias
TRNA Methyltransferase 10A RG9MTD2 TRM10 RNA (Guanine-9-)-Methyltransferase Domain-Containing Protein 2 TRNA (Guanine(9)-N(1))-Methyltransferase TRMT10A TRNA Methyltransferase 10 Homolog A MGC27034 RNA (Guanine-9-) Methyltransferase Domain Containing 2 TRNA Methyltransferase 10 Homolog A (S. Cerevisiae) Epididymis Secretory Protein Li 88 EC 2.1.1.221 HEL-S-88 MSSGM1 MSSGM
Location (GRCh38)
4:99546709-99564039
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001134665.3
Sequence length
3547.0 nt
GC content
0.3394

Transcripts

ID Sequence Length GC content
NM_001134665.3 NCBI
ACUGCGUAACUACCGCCCCUGCCUCUGGGAAUUGAAGUUUCUGUGGAAG… 3547 nt 0.3394
NM_001134666.3 NCBI
ACUGCGUAACUACCGCCCCUGCCUCUGGGAAUUGAAGUUUCUGUGGAAG… 3536 nt 0.3396
NM_001375880.1 NCBI
CUACCCAGCUGCUCCCUGGUUCGCCAGAGACAGCUUAAUCCCGUCUCUG… 3586 nt 0.3452
NM_001375881.1 NCBI
CUACCCAGCUGCUCCCUGGUUCGCCAGAGACAGCUUAAUCCCGUCUCUG… 3575 nt 0.3455
NM_001375882.1 NCBI
ACUGCGUAACUACCGCCCCUGCCUCUGGGAAUUGAAGUUUCUGUGGAAG… 3526 nt 0.3389
NM_152292.5 NCBI
CUACCCAGCUGCUCCCUGGUUCGCCAGAGACAGCUUAAUCCCGUCUCUG… 3765 nt 0.3538
Summary

This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Forensic Context

A study in mice demonstrated that acute alcohol exposure during neurulation induces rapid transcriptomic changes in the rostroventral neural tube, with the TRMT10A being down-regulated (-0.37 Log2FC) 4 hours post-exposure alongside other methyltransferase activity genes, indicating disrupted RNA methylation processes [Boschen et al. DOI:10.1016/J.Alcohol.2022.09.001].