Basic Information

Symbol
TRPC1
RNA class
mRNA
Alias
Transient Receptor Potential Cation Channel Subfamily C Member 1 HTRP-1 Short Transient Receptor Potential Channel 1 Transient Receptor Protein 1 TRP1 Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Capacitative Calcium Channel Protein Trp1 Transient Receptor Potential Canonical 1 TrpC1 TRP-1
Location (GRCh38)
3:142724034-142807888
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001251845.2
Sequence length
4561.0 nt
GC content
0.3973

Transcripts

ID Sequence Length GC content
NM_001251845.2 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 4561 nt 0.3973
NM_001413361.1 NCBI
AAAUUAAUACUACUUUCAGAUAAUUAAACUGUCAUACAGCGACUACAAA… 6050 nt 0.3355
NM_001413362.1 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 4327 nt 0.3973
NM_001413363.1 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 4315 nt 0.3968
NM_001413375.1 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 4406 nt 0.3983
NM_001413376.1 NCBI
AAAUUAAUACUACUUUCAGAUAAUUAAACUGUCAUACAGCGACUACAAA… 5948 nt 0.3342
NM_001413377.1 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 4304 nt 0.3980
NM_001413378.1 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 4262 nt 0.3982
NM_001413379.1 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 4160 nt 0.3978
NM_001413380.1 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 4028 nt 0.3982
Showing 1 to 10 of 13 entries
Summary

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Forensic Context

A study in mice and humans identified the TRPC1 as a top biomarker with sustained decreasing expression in leukocytes from the early to late recovery phases following severe burn injury [Xu et al. DOI:10.1159/000493451]. In a separate cross-species analysis of sepsis-induced myocardial dysfunction, the TRPC1 was mentioned as a gene previously confirmed to regulate the condition but was not experimentally studied in that investigation [Yao et al. DOI:10.1016/j.ygeno.2024.110911].