Basic Information

Symbol
TRPC1
RNA class
mRNA
Alias
Transient Receptor Potential Cation Channel Subfamily C Member 1 HTRP-1 Short Transient Receptor Potential Channel 1 Transient Receptor Protein 1 TRP1 Transient Receptor Potential Cation Channel, Subfamily C, Member 1 Capacitative Calcium Channel Protein Trp1 Transient Receptor Potential Canonical 1 TrpC1 TRP-1
Location (GRCh38)
3:142724034-142807888
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001251845.2
Sequence length
4561.0 nt
GC content
0.3973

Transcripts

ID Sequence Length GC content
NM_001413381.1 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 3838 nt 0.3971
NM_001413382.1 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 3683 nt 0.3983
NM_003304.5 NCBI
GUCGCUACAGAGGAGCAGAGGAUGACGUGAGGACAGAGUCGCGAACAUC… 4459 nt 0.3969
Showing 11 to 13 of 13 entries
Summary

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Forensic Context

A study in mice and humans identified the TRPC1 as a top biomarker with sustained decreasing expression in leukocytes from the early to late recovery phases following severe burn injury [Xu et al. DOI:10.1159/000493451]. In a separate cross-species analysis of sepsis-induced myocardial dysfunction, the TRPC1 was mentioned as a gene previously confirmed to regulate the condition but was not experimentally studied in that investigation [Yao et al. DOI:10.1016/j.ygeno.2024.110911].